孟 和

学历:博士   
职称: 教授
职务:上海交通大学 农业与生物学院 动物科学系主任
研究方向:
(1)动物基因组学及分子育种
(2)宿主与肠道微生物互作
通讯地址:上海市东川路800号,上海交通大学 农业与生物学院3-301室
邮编:200240 电话:021-34206146;15801798349  

E-mail: menghe@sjtu.edu.cn

 

教育背景
1982.09-1986.07 内蒙古农业大学, 畜牧专业,学士学位;
1986.09-1989.07 内蒙古农业大学, 动物遗传育种,硕士学位;
1999.09-2002.07 东北农业大学,动物遗传育种,博士学位;
2002.12-2004.12 上海交通大学,生物医学工程博士后流动站;
2007.05-2008.02 美国弗吉尼亚理工大学(VT),访问学者;
2010.08-2010.09 荷兰国家应用科学组织(TNO),访问学者;
2011.08-2011.11 美国弗吉尼亚理工大学(VT),访问学者;


学术团体
       世界家禽学会中国分会会员,中国畜牧兽医学会家禽学分会理事,上海市细胞生物学学会理事,中国遗传学会会员,中国细胞生物学学会会员,中国生物信息学会会员,中国农业生物技术学会会员,上海畜牧兽医学会理事,上海市畜禽种质资源保护和利用委员会委员。
教学工作
       主讲《动物育种学》、 《动物生物技术》、 《生命科学发展史》。主持项目“通识教育课程《生命科学发展史》的建设和应用”获2016年度上海交通大学校级教学成果二等奖;主持教改项目“本科实验教学课程体系建设及运行管理模式改革与探索 ”获2008年上海交通大学教学成果二等奖。主持完成"线虫基因沉默(RNA干扰)"2007年上海交通大学特色实验项目。主讲课程《生命科学发展史》2008年列为上海交通大学首批通识教育核心课程建设项目(已验收); 2011年度列为上海市教委重点课程立项建设项目(已验收);2013年被列为上海交通大学首批MOOC课程建设项目。2009至今被聘为上海交通大学通识教育核心课程专家。荣获2008-2009学年上海交通大学优秀教师二等奖;2008-2009学年上海交通大学实验室管理先进工作者;2013年获得上海交通大学通识教育贡献奖一等奖。荣获2013-2014学年上海交通大学优秀教师一等奖。
科学研究
       主持国家高技术研究发展计划(863计划)重点项目、国家自然基金面上项目、中国博士后科学基金,上海市自然基金,上海市科技兴农重点攻关项目等各级各类科研项目15项。在《Nature Communications》、《Scientific Reports》、《Molecular ﹠ Cellular Proteomics》、《 Animal Genetics》、《 Poultry Science》、《Journal of Dairy Science》、《Journal of Bacteriology》、《遗传学报》、《动物学报》、《微生物学报》等专业期刊上发表学术论文70余篇。
       世界首例双峰驼基因组计划发起人和主要完成人,成果2012年发表在Nature子刊《Nature Communications》(DOI: 10.1038/ncomms2192)。
       合作研究项目"益生菌L.caseiZhang的筛选及基因组学和蛋白质组学研究" 获2009年内蒙古自治区自然科学奖1等奖(排名第2)。

 

主要学术论文
1.       Guangliang Gao, Xianzhi Zhao, Qin Li, Chuan He, Wenjing Zhao, Shuyun Liu, Jinmei Ding, Weixing Ye, Jun Wang, Ye Chen, Haiwei Wang, Jing Li, Yi Luo, Jian Su, Yong Huang, Zuohua Liu, Ronghua Dai, Yixiang Shi, He Meng*, Qigui Wang*. Genome and metagenome reveals adaptive evolution of host and interaction with gut microbiota in goose. 2016,Scientific Reports | 6:32961 | DOI: 10.1038/srep32961
2.       Shuyun Liu, Lele Zhao, Zhengxiao Zhai, Wenjing Zhao, Jinmei Ding. Ronghua Dai, Tao Sun, He Meng*. Porcine Epidemic Diarrhea Virus Infection Induced the Unbalance of Gut Microbiota in Piglets. Curr Microbiol,2015, DOI 10.1007/s00284-015-0895-6.
3.       Wenjing Zhao, Yapeng Wang, Shuyun Liu, Jiaojiao Huang, Zhengxiao Zhai, Chuan He, Jinmei Ding, Jun Wang, Huijuan Wang, Weibing Fan, Jianguo Zhao, He Meng*. The Dynamic Distribution of Porcine Microbiota across Different Ages and Gastrointestinal Tract Segments. PLOS ONE, 2015, DOI:10.1371/journal.pone.0117441
4.       Zhengxiao Zhai, Wenjing Zhao, Chuan He, Kaixuan Yang, Linlin Tang, Shuyun Liu, Yan Zhang, Qizhong Huang and He Meng*. SNP discovery and genotyping using restriction-site-associated DNA sequencing in chickens. Animal Genetics, 2014, doi: 10.1111/age.12250.
5.       He Meng*., Yan Zhang *., Lele Zhao , Wenjing Zhao , Chuan He , Christa F. Honaker ,Zhengxiao Zhai , Zikui Sun , Paul B. Siegel*. Body Weight Selection Affects Quantitative Genetic Correlated Responses in Gut Microbiota. PLOS ONE.  2014 , 9 (3): e89862
6.       Na Qiao , Qi Liua, He Meng* , Dayun Zhao*.Haemolytic activity and adjuvant effect of soyasaponins and some of their derivatives on the immune responses to ovalbumin in mice. International Immunopharmacology.2014,18: 333–339
7.       Jinlong Huang, Yiping Zhao, Dongyi Bai, Wunierfu Shiraigol1, Bei Li1, Lihua Yang,Jing Wu, Wuyundalai Bao, Xiujuan Ren, Burenqiqige Jin, Qinan Zhao, Anaer Li,Sarula Bao, Wuyingga Bao, Zhencun Xing, Aoruga An, Yahan Gao, Ruiyuan Wei,Yirugeletu Bao, Taoketao Bao, Haige Han, Haitang Bai, Yanqing Bao, Yuhong Zhang,Dorjsuren Daidiikhuu, Wenjing Zhao, Shuyun Liu, Jinmei Ding, Weixing Ye, Fangmei Ding, Zikui Sun, Yixiang Shi, Yan Zhang*, He Meng *& Manglai Dugarjaviin*. Donkey genome and insight intothe imprinting of fast karyotype evolution. Scientific Reports.2015, 5:14106, DOI: 10.1038/srep14106.
8.       Jinlong Huang, Yiping Zhao, Wunierfu Shiraigol, Bei Li, Dongyi Bai, Weixing Ye,Dorjsuren Daidiikhuu, Lihua Yang, Burenqiqige Jin, Qinan Zhao, Yahan Gao, Jing Wu,Wuyundalai Bao, Anaer Li, Yuhong Zhang, Haige Han, Haitang Bai, Yanqing Bao, Lele Zhao,Zhengxiao Zhai, Wenjing Zhao, Zikui Sun, Yan Zhang, He Meng & Manglai Dugarjaviin*. Analysis of horse genomes providesinsight into the diversification andadaptive evolution of karyotype. Scientific Reports. 2014, 4 : 4958, DOI: 10.1038/srep04958.
9.       Lele Zhao, Gang Wang, Paul Siegel, Chuan He, Hezhong Wang, Wenjing Zhao, Zhengxiao Zhai, Fengwei Tian, Jianxin Zhao, Hao Zhang, Zikui Sun, Wei Chen, Yan Zhang& He Meng*. Quantitative Genetic Background of the Host Influences Gut Microbiomes in Chickens. Scientific Reports. 2013, 3:1163. doi:10.1038/srep01163
10.       Jirimutu, Zhen Wang, Guohui Ding, Gangliang Chen, Yamin Sun, Zhihong Sun, Heping Zhang, Lei Wang, Surong Hasi, Yan Zhang, Jianmei Li, Yixiang Shi, Ze Xu, Chuan He, Siriguleng Yu, Shengdi Li, Wenbin Zhang, Mijiddorj Batmunkh, Batsukh Ts, Narenbatu, Unierhu, Shirzana Bat-Ireedui, Hongwei Gao, Banzragch Baysgalan, Qing Li, Zhiling Jia, Turigenbayila, Subudenggerile, Narenmanduhu, Zhaoxia Wang, Juan Wang, Lei Pan, Yongcan Chen, Yaichil Ganerdene, Dabxilt, Erdemt, Altansha, Altansukh, Tuya Liu, Minhui Cao, Aruuntsever, Bayart, Hosblig, Fei He, A Zha-ti, Guangyong Zheng, Feng Qiu, Zikui Sun, Lele Zhao, Wenjing Zhao, Baohong Liu, Chao Li, Yunqin Chen, Xiaoyan Tang, Chunyan Guo, Wei Liu, Liang Ming, Temuulen, Aiying Cui, Yi Li, Junhui Gao, Jing Li, Wurentaodi, Shen Niu, Tao Sun, Zhengxiao Zhai, Min Zhang, Chen Chen, Tunteg Baldan, Tuman Bayaer, Yixue Li & He Meng *. Genome sequences of wild and domestic bactrian camels. Nature Communications. 2012 ,3:1202. doi: 10.1038/ncomms2192.
11.       Kaixuan Yang, Yongcan Chen, Caiju Gu, Zhenxiang Zhou,Chuan He, Linlin Tang, Shiyu Li, Lele
Zhao, He Meng*and Qizhong Huang*. Polydactyly mutation is linked to chromosome 2p region
in Beijing fatty chicken. Animal Genetics.2012, doi: 10.1111/j.1365-2052.2012.02369.x
12.       Jicheng Wang , Zhi Zhong , Wenyi Zhang , Qiuhua Bao , Aibin Wei , He Meng *, Heping Zhang *.Comparative analysis of the gene expression profile of probiotic Lactobacillus casei Zhang with and without fermented milk as a vehicle during transit in a simulated gastrointestinal tract. Research in Microbiologoy. 2012. 10.1016 /j.resmic..04.002.
13.       Jicheng Wang, Wenyi Zhang, Zhi Zhong, Aibin Wei, Qiuhua Bao, Yong Zhang,Tiansong Sun , Andrew Postnikoff, He Meng*, Heping Zhang*. Gene expression profile of probiotic Lactobacillus casei Zhang during the late stage of milk fermentation. Food Control.2012, 25:321-327.
14.       Ji-Cheng Wang.Wen-Yi Zhang.Zhi Zhong.Ai-Bin Wei.Qiu-Hua Bao.Yong Zhang.Tian-Song Sun.Andrew PostnikoV. He Meng*.He-Ping Zhang*. Transcriptome analysis of probiotic Lactobacillus casei Zhang during fermentation in soymilk. Journal of Industrial Microbiology and Biotechnology. 2011, DOI 10.1007/s10295-011-1015-7.
15.       Rina Wu, Wenyi Zhang, Tiansong Sun, Junrui Wu, Xiqing Yue, He Meng*, Heping Zhang*. Proteomic analysis of responses of a new probiotic bacterium Lactobacillus casei Zhang to low acid stress. International Journal of Food Microbiology.2011, 147:181–187.
16.       Zhi Zhong , Wenyi Zhang , Ruiting Du , He Meng *, Heping Zhang *. Lactobacillus casei Zhang stimulates lipid metabolism in hypercholesterolemic rats by affecting gene expression in the liver. European Journal of Lipid Science and Technology. 2011, DOI: 10.1002/ ejlt. 201100118.
17.       Wen Yi Zhang, Zhi Hong Sun,Dong Liang Yu, Caicike Airideng, Wei Chen, He Meng* ,He Ping Zhang*.Comparative analysis of iol clusters in Lactobacillus casei strains. World J Microbiol Biotechnol.2010,26:1949–1955.
18.       Wenyi Zhang,Dongliang Yu, Zhihong Sun, Rina Wu, Xia Chen, Wei Chen, He Meng*,Songnian Hu, and Heping Zhang*.Complete Genome Sequence of Lactobacillus casei Zhang, a New Probiotic Strain Isolated from Traditional Homemade Koumiss in Inner Mongolia China. Journal of Bacteriology.2010,190(19):5268–5269.
19.       R. Wu, Z. Sun, J. Wu, H. Meng*, H. Zhang*,Effect of bile salts stress on protein synthesis of Lactobacillus casei Zhang revealed by 2-dimensional gel electrophoresis. Journal of Dairy Science.2010,93(8): 3858-3868.
20.       L. H. Zhu, H. Meng*, X. J. Duan, G. Q. Xu, J. Zhang, and D. Q. Gong*.Gene expression profile in the liver tissue of geese after overfeeding. poultry science.2010,90:107-117.
21.       Zhihong Sun,Xia Chen, Jicheng Wang, Pengfei Gao, Zhemin Zhou,Yi Ren,Tiansong Sun,Lei Wang, He Meng, Wei Chen* and Heping Zhang*. Complete Genome Sequence of Probiotic Bifidobacterium animalis subsp. lactis Strain V9. Journal of Bacteriology.2010,192(15): 4080-4081.
22.       Zhang, W.,  D. Yu,  Z. Sun, W. Chen, S. Hu, H. Meng* and H. Zhang*.The comparative analysis of a prophage remnant Lcazh1 in relation to other Lactobacillus prophages, particularly Lp3.International Journal of Dairy Technology.2010,63(1): 1-5.
23.       XIA CHEN,ZHIHONG SUN,HE MENG* and HEPING ZHANG*.The acid tolerance association with expression of H+-ATPase in Lactobacillus casei. International Journal of Dairy Technology. 2009, 62( 2 ):272-276.
24.       Rina Wu, Weiwei Wang, Dongliang Yu, Wenyi Zhang, Yan Li, Zhihong Sun, Junrui Wu, He Meng* & Heping Zhang1*.Proteomic Analysis of Lactobacillus casei Zhang, a New Probiotic Bacterium Isolated from Traditional Home-made Koumiss in Inner Mongolia of China. Molecular ﹠ Cellular Proteomics,2009,8(10) 2321-2338.
25.       Rimutu Ji, Peng Cui, Feng Ding, Jianing Geng, Hongwei Gao, Heping Zhang, Jun Yu, Songnian Hu, and He Meng*.Monophyletic Origin of Domestic Bactrian Camel (Camelus bactrianus) and Evolutionary Relationship with the Extant Wild Camel (Camelus bactrianus ferus).Animal genetics,2009,40:377-382.
26.       H. Meng, H. Li , J.G. Zhao, Z. H. Li.Single Nucleotide Polymorphisms on Peroxisome Proliferator-activated Receptor Genes Associated with Fatness Traits in Chicken. Asian-Australasian Journal of Animal Sciences.2005,18(9):1221-1225.
27.       Wen Yi ZHANG, Ri Na WU, Zhi Hong SUN, Tian Song SUN, He MENG*, He Ping ZHANG*.Molecular cloning and characterization of bile salt hydrolase in Lactobacillus casei Zhang. Annals of Microbiology.2009, 59 (4) 721-726.
28.       Wen Yi ZHANG,Dong Liang YU, Zhi Hong SUN, Caicike AIRIDENG, Song Nian HU, He MENG*, He Ping ZHANG*.Preliminary analysis of glutathione S-transferase homolog from Lactobacillus casei Zhang. Annals of Microbiology.2009,59 (4) 727-731.
29.       H. MENG, F.Y. CUI, X.H. CHEN, Y.C. PAN. Inhibition of gene expression directed by small interfering RNAs in infectious bronchitis virus. Acta virologica.2007,51(4):265-269.
30.       Biao Dong,  Daoqing Gong, Zhiliang Gu, He Meng*. Molecular cloning and characterization of Rab6 gene in duck.DNA Sequence.2007,18 ( 4) :307 – 311.
31.       Xia CHEN, Zhi Hong SUN, He MENG*, He Ping ZHANG*.Molecular cloning and characterisation of gamma subunit of H+-ATPase in Lactobacillus acidophilus MG2-9.Annals of Microbiology. 2007, 57(3);415-418.
32.       Peng Cui, Rimutu Ji, Feng Ding, Dan Qi, Hongwei Gao, He Meng, Jun Yu,Songnian Hu, and Heping Zhang.A complete mitochondrial genome sequence of the wild two-humped camel (Camelus bactrianus ferus): an evolutionary history of camelidae. BMC Genomics. 2007,8 (241):1-10.
33.       Zhang, W., Yu, D., Sun, Z., Chen, X., Bao, Q., Meng, H., Hu, S., and Zhang, H. Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang. Plasmid. 2008,60(2):131-135.
34.       Jian-Guo Zhao, Hui Li, Yu-Xiang Wang, He Meng.The Expression Characterization of Chicken Uncoupling Protein Gene. Asian-Australasian Journal of Animal Sciences. 2005,18(11) : 1552 -1557.
35.       Chen X., Yang M., Sun Z., Liu W., Sun T., Meng H., Zhang H. Molecular Cloning and Characterisation of Alpha Subunit of H+-ATPase in Lactobacillus casei Zhang.Czech Journal of food sciences.2009,27( 1 ): 49–54.
36.       H. Meng, H. Li, J.G. Zhao,  Z.L.Gu. Differential expression of peroxisome proliferator activated receptors alpha and gamma gene in various chicken tissues. Domestic Animal Endocrinology.2005,28: 105-110.
37.       Chunyan Bai, He Meng, Wei Zhao, Yuchun Pan. Molecular cloning and characterization of monoamine oxidase A and B genes in pig. DNA Sequence.2005,16(3): 161–165.
38.       Yu, Dandan; Meng, He; Bai, Chunyan; Zhao, W.; Wang, Q. S.; Pan, Yuchun. Molecular cloning of nuclear receptor coactivator-1 gene in pig. DNA Sequence.2006,17(1):79-82.
39.       C.L. Li, Y.C. Pan and H. Meng. Polymorphism of the H-FABP, MC4R and ADD1 genes in the Meishan and four other pig populations in China. South African Journal of Animal Science.2006,36 (1) :1-6.
40.       LI Chang-long,PAN Yu-chun, MENG He, LI Jing, WANG Qi-shan. Cloning, Sequencing, and Characterization of Porcine Sterol Regulatory Element Binding Proteins-1c Gene. Journal of Shanghai Jiaotong University ( Science) , 2005,E-10, S1, 072~076.
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